Following a frenetic opening in a swirling wind on a poor surface, North Ferriby gradually took control and on 12 minutes took a deserved lead. Fine link play between Nathan Jarman and Lewis McMahon produced an opening for the surging run of Liam King who burst into the penalty area and drove his shot smartly passed the advancing keeper.
Histon gave themselves a mountain to climb when on 17 minutes full back Zac Mills was red carded for a lunging challenge on Danny Clarke, who although recovered had to be substituted at half time.
The home side found it difficult to handle Ferriby's smart football and were fortunate to reach the interval just a goal down.
Billy Heath introduced Danny Emerton for the re start and the debutant made an immediate impact with some fine wing play. Indeed, it was he that doubled the lead on 72 minutes when he rifled home from 12 yards following a flowing move involving fellow debutant Josh Wilde.
With 10 minutes remaining Emerton again unlocked the Histon rear-guard and presented Russ Fry with a shot that cannoned off a defender just over the crossbar. But the resultant corner from Jamie Yates found Lewis McMahon at the near post and he powered his header into the top corner to complete an assured 3-0 victory for the Villagers.